We report a case of primary cutaneous infection by the emerging fungus Aspergillus ustus in an immunosuppressed patient after a domestic accident. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A . Med Mycol. Jun;45(4) Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an.
Support Center Support Center. Aspergillus Fungi described in The band patterns from each asergillus with each primer were analyzed by using tools for population genetics analysis TFPGA unpub.
More studies will be necessary to determine the clinical consequence of antifungal resistance in A.
Nielsen KF Mycotoxin production by indoor molds. In-vitro testing of susceptibility to amphotericin B is a reliable predictor of clinical outcome in invasive aspergillosis. Information on timing of construction activities and airflow information was obtained from hospital engineering and infection control personnel.
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Fever, chills, and dyspnea, pulmonary consolidation. Patients 2, 4, 5, and 6 were moved to a variety of rooms around the time of diagnosis as indicated by their location in multiple rooms. The first occurred from July to October 3 probable lung infections: It is commonly found in indoor environments and soil. Acknowledgments We thank Estella Whimbey and Nancy Whittington for their help with acquiring information on hospital airflow and construction activity, Robin Olsen for performing the environmental air sampling, Chris Davis for database support, David Madtes and Pat McDowell for obtaining bronchoscopic information, and S.
We cannot comment on the role of water as a source of infection, which has been reported in multiple hospitals 32 His interests include the epidemiology of fungal infections.
Molecular Typing Molecular typing of A. These cases illustrate the potential for uncommon species like A.
Aspergillus ustus – Wikipedia
Random amplification of polymorphic DNA may give valuable clues about the clonality of A. In three of the cases, the patients required enucleation following cataract surgery, while the fourth involved a fatal infection in a pediatric patient hospitalized for osteopetrosis. From Wikipedia, the free encyclopedia. We report here the first cluster of Aspergillus ustus endophthalmitis cases which occurred in a large tertiary care hospital during the period October to June Multilobar pneumonia, thyroid, lung, kidney, peritoneum abscesses.
A source investigation of this mini outbreak was performed by environmental sampling, but no isolates of A. The median age of patients was 59 range 29 years; 5 For example, swabbing of dust-ridden surfaces may have indicated the underlying air quality in terms of fungal spores in the preceding months when infection may have occurred.
We thank Estella Whimbey and Nancy Whittington for their help with acquiring information on hospital airflow and construction activity, Robin Olsen for performing the environmental air sampling, Chris Davis for database support, David Madtes and Pat McDowell for obtaining bronchoscopic information, and S.
Aspergillus ustus endophthalmitis is a serious and devastating complication of ocular surgery. No changes in laboratory processing or mold identification methods occurred during the study. We report the first outbreak of invasive infection caused by A. Ascioglu S, Rex JH, de Pauw J Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: In other projects Wikimedia Commons.
The spectrum of disease reported due to A. Drug exposure may select for colonization or infection with resistant isolates or facilitate acquired resistance within a colonizing strain. Clinical isolates exhibited decreased susceptibility to antifungal drugs, especially azoles.
Aspergillus ustus Infections among Transplant Recipients
This article has been cited by other articles in PMC. Aspeggillus of infection caused by A. Aspergillus ustus is among the most ubiquitous soil species but it is more frequently found in tropical and subtropical areas.
Similarly, the isolate from patient 1 was genetically most similar to that of patient 4; patients 1 and 4 resided in adjacent rooms, also separated by a period of 2 years. Sharp, demarcated white areas over dorsal hands and arms.